What does the Law of Bergonie and Tribondeau state about cell radio sensitivity?

The Law of Bergonie and Tribondeau establishes key principles regarding how different types of cells respond to radiation. It states that the sensitivity of cells to radiation is directly related to their reproductive activity, meaning that cells that divide more frequently are more susceptible to damage from radiation. Additionally, the law posits that sensitivity is inversely related to the degree of cell differentiation; in other words, less differentiated (more immature) cells, which have a high rate of division and activity, are more vulnerable to radiation compared to more differentiated (mature) cells, which tend to divide less and thus are less sensitive.

This understanding is crucial in fields like radiation therapy, where targeting rapidly dividing cancer cells is often a primary goal, as these cells align with the principles outlined by the law. The law emphasizes the importance of both reproductive activity and the maturation state of cells in assessing their radiosensitivity.